For intramuscular use only;

Indication:

Drostanolone Propionate is used in the treatment of breast cancer in elderly post-menopausal as a second therapy of unspecific immunotherapy.

Contraindications:

This medicine is not indicated to be used in children therapy. Masteron is contraindicated in male bodybuilders with carcinoma of the breast or with known or suspected carcinoma of the prostate and in female bodybuilders who can be pregnant. Drostanolone Propionate Inj. is also not allowed in bodybuilders that have a hypersensitivity to something in its composition.

2α-Methyl-4,5α-dihydrotestosterone 17β-propionate, known as drostanolone propionate or masteron, is a synthetic anabolic-androgenic steroid derived from dihydrotestosterone. The crystal structures of two polymorphs of drostanolone propionate have been determined by single crystal X-ray diffraction and both crystallizes in the monoclinic crystal system. One is belonging to the P2₁ space group, Z = 2, and has one molecule in the asymmetric unit while the second belongs to the I2 space group, Z = 4, and contains two molecules in the asymmetric unit. Another polymorph has been investigated by an X-ray powder diffraction method and solved by Parallel tempering/Monte Carlo technique and refined with the Rietveld method. This polymorph crystallizes in the orthorhombic P2₁2₁2₁ space group, Z = 4 having one molecule in the asymmetric unit. The structural configuration analysis shows that the A, B, and C steroid rings exist as chair geometry, while ring D adopts a C13 distorted envelope configuration in all structures. For all polymorphs, the lattice energy has been computed by CLP (Coulomb-London-Pauli), and tight-binding density functional theory methods. Local electron correlation methods were used to estimate the role of electron correlation in the magnitude of the dimer energies. The nature of the intermolecular interactions has been analyzed by the SAPT0 energy decomposition methods as well as by Hirshfeld surfaces.

Administration:

The optimally administered dose is 100 mg – 200 mg every 2-3 days. The most effective dose that brings effective results consists of 400 mg / week.

The polymorphism in organic compounds is the ability to exist in several crystalline forms. The polymorphs have similar chemical content but exhibit different crystal packing and arrangement [1]. Androgens represent a class of compounds, which can be synthetic or naturally found in vertebrates that are responsible for development and maintenance of male characteristics. The anabolic component of a certain anabolic-androgenic steroid is related to increased protein synthesis in muscle tissues and bones, while the androgenic component is responsible for the development of secondary male characteristics such as deepening of the voice, facial and body hair growth, and aggressiveness. Synthetic androgens are chemically-modified forms of the primary male hormone, testosterone, with the purpose to lower the androgenic characteristics and increase the anabolic properties [2]. Despite the fact that anabolic-androgenic steroids fulfill certain functions in vertebrates and are very effective to boost sports performance, their misuse and abuse can lead to undesirable, serious negative side effects on health. Heart diseases (hypertension, left ventricular hypertrophy, impaired diastolic filling, polycythemia, and thrombosis) are known to be related to the long-term consumption of anabolic steroids [3]. A decrease in the high density lipoprotein (HDL), concomitant with an increase in a low density lipoprotein (LDL) and total cholesterol, are related to the consumption as well, which may increase the risk of atherosclerosis in the coronary arteries [4,5,6]. Hypogonadism induced by anabolic steroids in males and the development of male characteristics in women and children are regarded as having milder side effects and they are reversible to some extent [7]. Besides the anabolic properties of the derivatives in this group, they can be useful in certain medical conditions, which cause undesired catabolism and loss of muscle mass. They act as anti-catabolic, which negates the effects of cortisol and the derivatives from glucocorticoids class [7,8].